Seong-wook Park

Publications

1. Chang Kyung Kang#, Min-Gang Kim#, Seong-wook Park#, Yong-Woo Kim, Chan Mi Lee, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Minji Kim, Soojin Lee, Ik Soo Kim, Chang-Han Lee*, Hyun Mu Shin*, Hang-Rae Kim*, Myoung-don Oh*

# Co-first author, *Co-corresponding author Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted individuals  Journal of Medical Virology (IF: 20.693), accepted

2. Seong-Wook Park, Da-Som Lee, and Yong-Sung Kim*.  Engineering a U-box of E3 ligase E4B through yeast surface display-based functional screening generates a variant with enhanced ubiquitin ligase activity. Biochemical and Biophysical Research Communications, 2022 July 5, 612:147-153.

3. Seong-Wook Park, Sei-Yong Jun, Ji-Sun Kim, Yong-Sung Kim*. Engineering of an EpCAM-targeting cyclic peptide to improve the EpCAM-mediated cellular internalization and tumor accumulation of a peptide-fused antibody. Biochemical and Biophysical Research Communications, 2021 October 8, 573:35-41.

4. Seung-Min Shin, Ji-Sun Kim, Seong-Wook Park, Sei-Yong Jun, Hye-Jin Kweon, Dong-Ki Choi, Dakeun Lee, Yong Beom Cho, Yong-Sung Kim*. Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth. Science Advances, 2020 January, 6(3): eaay2174.

5. Ji-sun Kim, Jae-Yeong Park, Seung-Min Shin, Seong-Wook Park, Sei-Yong Jun, Jin-Sun Hong, Dong-Ki Choi, Yong-Sung Kim*. Engineering of a tumor cell–specific, cytosol-penetrating antibody with high endosomal escape efficacy. Biochemical and Biophysical Research Communications, 2018. September 18; 503(4):2510-2516.

6. Seung-Min Shin, Dong-Ki Choi, Keunok Jung, Jeomil Bae, Ji-sun Kim, Seong-Wook Park, Ki-Hoon Song, and Yong-Sung Kim*. Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumor effects after systemic administration. Nature Communications, 2017. 8:15090. 

7.  Ji-Sun Kim, Dong-Ki Choi, Ju-Yeon Shin, Seung-Min Shin, Seong-Wook Park, Hyun-Soo Cho, Yong-Sung Kim*. Endosomal acidic pH-induced conformational changes of a cytosol-penetrating antibody mediate endosomal escape. Journal of Controlled Release, 2016. Aug 10, 235:165-175.

8. Seung Eui Min, Kyung-Ho Lee, Seong-Wook Park, Tae Hyun Yoo, Chan Hee Oh, Ji-Ho Park, Sung Yun Yang, Yong-Sung Kim, and Dong-Myung Kim*. Cell-free production and streamlined assay of cytosol-penetrating antibodies. Biotechnology and Bioengineering, 2016. Oct;113(10):2107-2112.

9. Ji-Sun Kim, Dong-Ki Choi, Seong-Wook Park, Seung-Min Shin, Jeomil Bae, Dong-Myung Kim, Tae Hyeon Yoo, and Yong-Sung Kim*. Quantitative assessment of cellular uptake and cytosolic access of antibody in living cells by an enhanced split GFP complementation assay. Biochemical and Biophysical Research Communication, 2015 Nov 27, 467(4):771-777.

 

Patent and Technology Transfer

1. Patent: CELL/TISSUE-SPECIFIC CELL-PENETRATING ANTIBODIES. (US 10,787,487 B2, USA)

2. Patent: ENHANCED SPLIT-GFP COMPLEMENTATION SYSTEM, AND USE THEREOF. (10-1790669, KOREA)

3. Patent: ANTIBODY WHICH INTERNALIZE INTO THE CYTOSOL OF CELLS AND BINDS TO INHIBIT ACTIVATED RAS AND USE THEREOF. (10-2018-0141770, KOREA)

​