top of page

The Lee Lab's publications

We are proud of our  achievements

Featured Publications

Journal of Medical Virology (IF: 20.693)

Will ETA Antibodies Arouse New Interest in Cancer Therapeutics?

Trends in Pharmacological Sciences (IF:17.638)

Nature Immunology

(IF: 31.250)

Broad humoral and cellular immunity elicited by one dose mRNA vaccination 18 months after SARS-CoV-2 infection

BMC Medicine (IF: 11.806)





IK Soo Kim#, Chang Kyung Kang#, Seung Jae Lee#, Chang-Han Lee#, Minji Kim, Chaehwa Seo, Gwanghun Kim, Soojin Lee, Kyoung Sun Park, Euijin Chang, Jongtak Jung, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh, Jong-Eun Lee, Hang-Rae Kim, Hyun Mu Shin*, and Hang-Rae Kim*

# Co-first author, *Co-corresponding author

Tracking Antigen-Specific TCR Clonotypes in SARS-CoV-2 Infection Reveals Distinct Severity Trajectories




Chan Mi Lee#, Minji Kim#, Seong-wook Park#, Chang Kyung Kang#, Pyoeng Gyun Choe, Nam Joong Kim, Hyun Mu Shin, Chang-Han Lee*, Hyun Mu Shin*, Hang-Rae Kim*, Wan Beom Park*, and Myoung-don Oh

# Co-first author, *Co-corresponding author

Clinical outcomes and immunologic features of COVID-19 in patients receiving B-cell depleting therapy in the Omicron era




Chan Mi Lee#, Pyoeng Gyun Choe#, Chang Kyung Kang#, Eunyoung Lee, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim, Hang-Rae Kim, Youngju Kim, Chang-Han Lee, Hyun Mu Shin*, Sang-Won Park*, Wan Beom Park*, and Myoung-don Oh

# Co-first author, *Co-corresponding author

Low humoral and cellular immune responses early fater breakthrough infection may contribute to severe COVID-19


Frontiers in Immunology (IF: 8.787),


Chang Kyung Kang#, Min-Gang Kim#, Seong-wook Park#, Yong-Woo Kim, Chan Mi Lee, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Minji Kim, Soojin Lee, Ik Soo Kim, Chang-Han Lee*, Hyun Mu Shin*, Hang-Rae Kim*, Myoung-don Oh*

# Co-first author, *Co-corresponding author

Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted individuals 

Journal of Medical Virology (IF: 20.693), doi: 10.1002/jmv.28558, Feb 8 (2023)

한빛사 소개



Chanho Kong#, Eun-Jeong Yang#, Jaewoo Shin#, Junwon Park, Si-Hyun Kim, Seong-Wook Park, Won Seok Chang, Chang-Han LeeHyunju Kim*, Hye-Sun Kim*, Jin Woo Chang*

# Co-first author, *Co-corresponding author

Enhanced delivery of low-dose of aducanumab via FUS in 5xFAD mice, an AD model

Translational Neurodegeneration (IF: 9.883), 11, Article number: 57 (2022) 


Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon & Sang-Kyu Ye

The acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells

BMC Cancer (IF:4.638),  22, Article number: 852 (2022)


Jinyong Kim#, Jiyun Jeong#, Chan Mi Lee, Dae-Won Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Nam Joong Kim, Myoung-don Oh, Chang-Han Lee, Wan Beom Park*, Kyung-Hun Lee*, and Seock-Ah Im

# Co-first author, *Co-corresponding author

Prospective Longitudinal Analysis of Antibody Response after standard and booster doses of SARS-COV2 vaccination in patients with early breast cancer

Frontiers in Immunology (IF: 8.787), 17 November 2022,


Chang Kyung Kang#, Hyun Mu Shin#, Pyoeng Gyun Choe#Jiyoung Park,  Jisu Hong, Jung Seon Seo, Yung Hie Lee, Euijin Chang, Nam Joong Kim, Minji Kim, Yong-Woo Kim, Hang-Rae Kim, Chang-Han Lee*, Jun-Young Seo*, Wan Beom Park*, Myoung-don Oh

# Co-first author, *Co-corresponding author

Broad humoral and cellular immunity elicited by one dose mRNA vaccination 18 months after SARS-CoV-2 infection

BMC Medicine (IF: 11.806), 20, 181 (2022).

서울대 홈페이지 소개

한빛사 소개



Pyoeng Gyun Choe#, Jisu Hong#, Jiyoung Park, Euijin Chang, Chang Kyung Kang, Nam Joong Kim, Chang-Han Lee*, Wan Beom Park*, and Myoung-don Oh

# Co-first author, *Co-corresponding author

Persistent Antibody Responses up to 18 Months after Mild SARS-CoV-2 Infection

Journal of Infectious Diseases (IF: 7.759), 17 March 2022


Chang Kyung Kang#, Minji Kim#, Jisu Hong#, Gwanghun Kim, Soojin Lee, Pyoeng Gyun Choe, Nam Joong Kim, Ik Soo Kim, Jun-Young Seo, Daesub Song, Dong-Sup Lee,  Hyun Mu Shin, Chang-Han Lee*, Wan Beom Park*, Hang-Rae Kim* and Myoung-don Oh

# Co-first author, *Co-corresponding author

Distinctive immune response after one-year post COVID-19 according to the severity

Frontiers in Immunology (IF: 8.787), 21 March 2022, vol 13, 830433


Han-Seok Jeong, Da-Hye Lee, Seung-Hoon Kim, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Chung-Hyun Cho*

Hyperglycemia-induced oxidative stress promotes tumor metastasis by upregulating vWF expression in endothelial cells through the transcription factor GATA1

Oncogene (IF: 8.756), January 29, 2022



Jiyoung Park and Chang-Han Lee*

Will ETA Antibodies Arouse New Interest in Cancer Therapeutics?

Trends in Pharmacological Sciences (IF:17.638), December 09, 2021

한빛사 소개


Chang‐Han Lee and George Delidakis

Chapter 13. Engineering IgG1 Fc domains that activate the complement system

Methods in Molecular Biology - Immune Receptors (MIMB, volume 2421) pp 187-200 December 7 2021; 8 (5)


Jie Li, Sam A Bazzi, Florian Schmitz, Hidetaka Tanno, Jonathan R McDaniel, Chang-Han Lee, Chaitanya Joshi, Jin Eyun Kim, Nancy Monson, Benjamin M Greenberg, Kristina Hedfalk, Esther Melamed, and Gregory C Ippolito


Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder

Neurol Neuroimmunol Neuroinflamm (IF: 11.360), September 2021; 8 (5)


Seung Hyun Kang and Chang‐Han Lee

Development of therapeutic antibodies and modulating the characteristics of therapeutic antibodies to maximize the therapeutic efficacy

Biotechnology and Bioprocess Engineering (IF:3.386), 2021, June 28


Chang Kyung Kang*, Minji Kim*, Soojin Lee, Gwanghun Kim, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Chang‐Han Lee, Ik Soo Kim, Keehoon Jung, Dong-Sup Lee,  Hyun Mu Shin, Hang-Rae Kim*, and Myoung-don Oh*


Longitudinal Analysis of Human Memory T-Cell Response according to the Severity of Illness up to 8 Months after SARS-CoV-2 Infection

Journal of Infectious Diseases (IF: 7.759), 2021, Mar 23

Before 2021


Aram Lyu,* Todd A. Triplett,* Seo Hee Nam, Zicheng Hu, Dhivya Arasappan, Wesley H. Godfrey, Rachel Y. Ames, Adviti Sarang, Hilary J. Selden, Chang‐Han Lee, George Georgiou, Terzah M. Horton, Lauren I. R. Ehrlich


Tumor-associated myeloid cells provide critical support for T-ALL.


Blood (IF: 23.629) 2020 July 7


Jiwon Lee, Bryan S. Der, Christos S. Karamitros, Wenzong Li, Nicholas M. Marshall, Oana I. Lungu, Aleksandr E. Miklos, Jianqing Xu, Tae Hyun Kang, Chang‐Han Lee, Bing Tan, Randall A. Hughes, Sang Taek Jung, Gregory C. Ippolito, Jeffrey J. Gray, Yan Zhang, Brian Kuhlman, George Georgiou*, Andrew D. Ellington* 


Computer‐based engineering of thermostabilized antibody fragments.

AIChE Journal (IF: 3.993) 2019 Nov 19


Chang-Han Lee, Tae Hyun Kang†, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew. J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter Tessier, Aaron S. Meyer, Pierre Bruhns*, and George Georgiou*

An Engineered Human Fc Domain that Behaves like a pH-Toggle Switch for Ultra-Long Circulation Persistence.

Nature Communications (IF: 14.919) 2019 Nov 6 10:5031 († equally contributed). 


Tae Hyun Kang†, Chang-Han Lee, George Delidakis, Jiwon Jung, Odile Richard-Le Goff, Jiwon Lee, Jin Eyun Kim, Wissam Charab, Pierre Bruhns, and George Georgiou* (2019)

An Engineered Human Fc variant with Exquisite Selectivity for FcγRIIIaV158 Reveals that Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis with GM-CSF-differentiated Macrophages.

Frontiers in Immunology (IF: 7.561) 2019 Mar. 27. 10: 562 († equally contributed).


Jonathan R McDaniel, Stephanie C Pero, William N Voss, Girja S Shukla, Yujing Sun, Sebastian Schaetzle, Chang-Han Lee, Andrew P Horton, Seth Harlow, Jimmy Gollihar, Jared W Ellefson, Christopher C Krag, Yuri Tanno, Nikoletta Sidiropoulos, George Georgiou, Gregory C Ippolito, David N Krag* (2018)

Identification of Tumor-Reactive B Cells and Systemic IgG in Breast Cancer Based on Clonal Frequency in the Sentinel Lymph Node.

Cancer Immunology Immunotherapy (IF: 6.968) 2018 May; 67(5): 729-738


Chang-Han Lee, Gabrielle Romain, Wupeng Yan, Makiko Watanabe, Wissam Charab, Biliana Todorova, Jiwon Lee, Kendra Triplett, Moses Donkor, Oana I. Lungu, Anja Lux, Nicholas Marshall, Odile RICHARD-LE GOFF, Tae Hyun Kang, Hidetaka Tanno, George Delidakis, Corrine Alford, Ronald P. Taylor, Falk Nimmerjahn, Navin Varadarajan, Pierre Bruhns, Yan Jessie Zhang and George Georgiou* (2017)

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector function.

Nature Immunology (IF: 25.606) 2017 Aug; 18(8): 889-898.

* This article was highlighted by Cees E van der Poel & Michael C Carroll “Untangling Fc and complement receptors to kill tumors” in Nature Immunology

* Also highlighted by APS (Advanced Photon Source) and ALS.

* This article was recommended by Cancer Immunology Research Journal, “What we’re reading”


Jiwon Lee, Daniel R. Boutz, Veronika Chromikova, M. Gordon Joyce, Christopher Vollmers, Kwanyee Leung, Andrew P. Horton, Brandon J. DeKosky, Chang-Han Lee, Jason J. Lavinder, Ellen M. Murrin, Constantine Chrysostomou, Kam Hon Hoi, Yaroslav Tsybovsky, Paul V. Thomas, Aliaksandr Druz, Baoshan Zhang, Yi Zhang, Lingshu Wang, Wing-Pui Kong, Daechan Park, Lyubov I. Popova, Cornelia L. Dekker, Mark M. Davis, Chalise E. Bloom, Ted M. Ross, Andrew D. Ellington, Patrick C. Wilson, Edward M. Marcotte, John R. Mascola, Gregory C. Ippolito, Florian Krammer, Stephen R. Quake, Peter D. Kwong, George Georgiou* (2016)

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.

Nature Medicine (IF: 53.440) 2016 Dec; 22(12):1456-1464.

Commentaries and News Stories: Covered by >20 scientific and mainstream media publications


Bo Wang, Chang-Han Lee, Erik Johnson, Christien A. Kluwe, Josephine Cunningham, Hidetaka Tanno, Richard Crooks, George Georgiou, and Andrew D. Ellington* (2016)

Discovery of High Affinity anti-Ricin Antibodies by B Cell Receptor Sequencing and by Yeast Display of Combinatorial V-H:V-L Libraries from Immunized Animals.

Mabs 2016 Jun 24; 8(6): 1035-1044.


Bo Wang, Christien A. Kluwe, Oana I. Lungu, Brandon J. DeKosky, Scott A. Kerr, Erik L. Johnson, Jiwon Jung, Hidetaka Tanno, Chang-han Lee, Alec B. Rezigh, Sean M. Carroll, Ann N. Reyes, Janelle R. Bentz, Itamar Villanueva, Amy L. Altman, Robert A. Davey, Andrew D. Ellington and George Georgiou* (2015)

Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining.

Scientific Reports. 2015 Sep 10; 5:13926. Erratum in: Scientific Reports. 2016 Jun 10;6:27229


William Kelton, Nishant Mehta, Wissam Charab, Jiwon Lee, Chang-han Lee, Takaaki Kojima, Tae Hyun Kang, and George Georgiou* (2014)


IgGA: A “Cross-Isotype” Engineered Human Fc Antibody Domain that Displays Both IgG-like and IgA-like Effector Functions.


Chemistry & Biology 2014 Dec 18; 21(12): 1603-1609


Kyung-Jin Park, Chang-Han Lee, Aeyung Kim, Ki Jun Jeong, Chul-Ho Kim, and Yong-Sung Kim* (2012)

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death.


Journal of Biological Chemistry. January 2012, 287(5): 3313-3325.


Seung Hoon Jang, Chang Han Lee, Yong Sung Kim, and Ki Jun Jeong* (2011)

High-level production of a kringle domain variant by high-cell-density cultivation of Escherichia coli.

Applied Microbiology and Biotechnology. 2011 Oct; 92(2): 327-336.


Chang-Han Lee, Kyung-Jin Park, Sang Jick Kim, Ohsuk Kwon, Ki Jun Jeong, Ayeung Kim, and Yong-Sung Kim* 

Generation of bivalent and bispecific Kringle single domains by loop grafting as potent agonists against death receptor 4 and 5.

Journal of Molecular Biology. 2011 August 5; 411 (1):201-219.


Chang-Han Lee, Kyung-Jin Park, Eun-Sil Sung, Aeyung Kim, Ji-Da Choi, Jeong-Sun Kim, Soo-Hyun Kim, Myung-Hee Kwon, Yong-Sung Kim*

Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America. 2010 May 11; 107:9567-9571.


Chang-Han Lee, Dong-Ki Choi, Hye-Ji Choi, Moo-Young Song, and Yong-Sung Kim* (2010)

Expression of soluble and functional human neonatal Fc receptor in Pichia pastoris.


Protein Expression and Purification. 2010 May 1, 71:42-48.


Kyung-Jin Park, Seung-Hyun Lee, Chang-Han Lee, Ji-Young Jang, Junho Chung, Myoung-Hee Kwon, Yong-Sung Kim* (2009)

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death.

Biochemical and Biophysical Research Communications. 2009. May 15; 382(4):726-9.


Kyung-Jin Park, Seung-Hyun Lee, Tae-In Kim, Hae-Won Lee, Chang-Han Lee, Eun-Hee Kim, Ji-Young Jang, Kyeong Sook Choi, Myung-Hee Kwon*, and Yong-Sung Kim* (2007)

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and resistant cancer cells. 

Cancer Research. 2007 Aug 1; 67 (15), 7327-7334.

bottom of page