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The Lee Lab's publications

We are proud of our  achievements

Before 2021


Aram Lyu,* Todd A. Triplett,* Seo Hee Nam, Zicheng Hu, Dhivya Arasappan, Wesley H. Godfrey, Rachel Y. Ames, Adviti Sarang, Hilary J. Selden, Chang‐Han Lee, George Georgiou, Terzah M. Horton, Lauren I. R. Ehrlich


Tumor-associated myeloid cells provide critical support for T-ALL.


Blood (IF: 23.629) 2020 July 7


Jiwon Lee, Bryan S. Der, Christos S. Karamitros, Wenzong Li, Nicholas M. Marshall, Oana I. Lungu, Aleksandr E. Miklos, Jianqing Xu, Tae Hyun Kang, Chang‐Han Lee, Bing Tan, Randall A. Hughes, Sang Taek Jung, Gregory C. Ippolito, Jeffrey J. Gray, Yan Zhang, Brian Kuhlman, George Georgiou*, Andrew D. Ellington* 


Computer‐based engineering of thermostabilized antibody fragments.

AIChE Journal (IF: 3.993) 2019 Nov 19


Chang-Han Lee†, Tae Hyun Kang†, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew. J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter Tessier, Aaron S. Meyer, Pierre Bruhns*, and George Georgiou*

An Engineered Human Fc Domain that Behaves like a pH-Toggle Switch for Ultra-Long Circulation Persistence.

Nature Communications (IF: 14.919) 2019 Nov 6 10:5031 († equally contributed). 


Tae Hyun Kang†, Chang-Han Lee†, George Delidakis, Jiwon Jung, Odile Richard-Le Goff, Jiwon Lee, Jin Eyun Kim, Wissam Charab, Pierre Bruhns, and George Georgiou* (2019)

An Engineered Human Fc variant with Exquisite Selectivity for FcγRIIIaV158 Reveals that Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis with GM-CSF-differentiated Macrophages.

Frontiers in Immunology (IF: 7.561) 2019 Mar. 27. 10: 562 († equally contributed).


Jonathan R McDaniel, Stephanie C Pero, William N Voss, Girja S Shukla, Yujing Sun, Sebastian Schaetzle, Chang-Han Lee, Andrew P Horton, Seth Harlow, Jimmy Gollihar, Jared W Ellefson, Christopher C Krag, Yuri Tanno, Nikoletta Sidiropoulos, George Georgiou, Gregory C Ippolito, David N Krag* (2018)

Identification of Tumor-Reactive B Cells and Systemic IgG in Breast Cancer Based on Clonal Frequency in the Sentinel Lymph Node.

Cancer Immunology Immunotherapy (IF: 6.968) 2018 May; 67(5): 729-738


Chang-Han Lee, Gabrielle Romain, Wupeng Yan, Makiko Watanabe, Wissam Charab, Biliana Todorova, Jiwon Lee, Kendra Triplett, Moses Donkor, Oana I. Lungu, Anja Lux, Nicholas Marshall, Odile RICHARD-LE GOFF, Tae Hyun Kang, Hidetaka Tanno, George Delidakis, Corrine Alford, Ronald P. Taylor, Falk Nimmerjahn, Navin Varadarajan, Pierre Bruhns, Yan Jessie Zhang and George Georgiou* (2017)

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector function.

Nature Immunology (IF: 25.606) 2017 Aug; 18(8): 889-898.

* This article was highlighted by Cees E van der Poel & Michael C Carroll “Untangling Fc and complement receptors to kill tumors” in Nature Immunology

* Also highlighted by APS (Advanced Photon Source) and ALS.

* This article was recommended by Cancer Immunology Research Journal, “What we’re reading”


Jiwon Lee, Daniel R. Boutz, Veronika Chromikova, M. Gordon Joyce, Christopher Vollmers, Kwanyee Leung, Andrew P. Horton, Brandon J. DeKosky, Chang-Han Lee, Jason J. Lavinder, Ellen M. Murrin, Constantine Chrysostomou, Kam Hon Hoi, Yaroslav Tsybovsky, Paul V. Thomas, Aliaksandr Druz, Baoshan Zhang, Yi Zhang, Lingshu Wang, Wing-Pui Kong, Daechan Park, Lyubov I. Popova, Cornelia L. Dekker, Mark M. Davis, Chalise E. Bloom, Ted M. Ross, Andrew D. Ellington, Patrick C. Wilson, Edward M. Marcotte, John R. Mascola, Gregory C. Ippolito, Florian Krammer, Stephen R. Quake, Peter D. Kwong, George Georgiou* (2016)

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.

Nature Medicine (IF: 53.440) 2016 Dec; 22(12):1456-1464.

Commentaries and News Stories: Covered by >20 scientific and mainstream media publications


Bo Wang, Chang-Han Lee, Erik Johnson, Christien A. Kluwe, Josephine Cunningham, Hidetaka Tanno, Richard Crooks, George Georgiou, and Andrew D. Ellington* (2016)

Discovery of High Affinity anti-Ricin Antibodies by B Cell Receptor Sequencing and by Yeast Display of Combinatorial V-H:V-L Libraries from Immunized Animals.

Mabs 2016 Jun 24; 8(6): 1035-1044.


Bo Wang, Christien A. Kluwe, Oana I. Lungu, Brandon J. DeKosky, Scott A. Kerr, Erik L. Johnson, Jiwon Jung, Hidetaka Tanno, Chang-han Lee, Alec B. Rezigh, Sean M. Carroll, Ann N. Reyes, Janelle R. Bentz, Itamar Villanueva, Amy L. Altman, Robert A. Davey, Andrew D. Ellington and George Georgiou* (2015)

Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining.

Scientific Reports. 2015 Sep 10; 5:13926. Erratum in: Scientific Reports. 2016 Jun 10;6:27229


William Kelton, Nishant Mehta, Wissam Charab, Jiwon Lee, Chang-han Lee, Takaaki Kojima, Tae Hyun Kang, and George Georgiou* (2014)


IgGA: A “Cross-Isotype” Engineered Human Fc Antibody Domain that Displays Both IgG-like and IgA-like Effector Functions.


Chemistry & Biology 2014 Dec 18; 21(12): 1603-1609


Kyung-Jin Park, Chang-Han Lee, Aeyung Kim, Ki Jun Jeong, Chul-Ho Kim, and Yong-Sung Kim* (2012)

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death.


Journal of Biological Chemistry. January 2012, 287(5): 3313-3325.


Seung Hoon Jang, Chang Han Lee, Yong Sung Kim, and Ki Jun Jeong* (2011)

High-level production of a kringle domain variant by high-cell-density cultivation of Escherichia coli.

Applied Microbiology and Biotechnology. 2011 Oct; 92(2): 327-336.


Chang-Han Lee, Kyung-Jin Park, Sang Jick Kim, Ohsuk Kwon, Ki Jun Jeong, Ayeung Kim, and Yong-Sung Kim* 

Generation of bivalent and bispecific Kringle single domains by loop grafting as potent agonists against death receptor 4 and 5.

Journal of Molecular Biology. 2011 August 5; 411 (1):201-219.


Chang-Han Lee, Kyung-Jin Park, Eun-Sil Sung, Aeyung Kim, Ji-Da Choi, Jeong-Sun Kim, Soo-Hyun Kim, Myung-Hee Kwon, Yong-Sung Kim*

Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America. 2010 May 11; 107:9567-9571.


Chang-Han Lee, Dong-Ki Choi, Hye-Ji Choi, Moo-Young Song, and Yong-Sung Kim* (2010)

Expression of soluble and functional human neonatal Fc receptor in Pichia pastoris.


Protein Expression and Purification. 2010 May 1, 71:42-48.


Kyung-Jin Park, Seung-Hyun Lee, Chang-Han Lee, Ji-Young Jang, Junho Chung, Myoung-Hee Kwon, Yong-Sung Kim* (2009)

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death.

Biochemical and Biophysical Research Communications. 2009. May 15; 382(4):726-9.


Kyung-Jin Park, Seung-Hyun Lee, Tae-In Kim, Hae-Won Lee, Chang-Han Lee, Eun-Hee Kim, Ji-Young Jang, Kyeong Sook Choi, Myung-Hee Kwon*, and Yong-Sung Kim* (2007)

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and resistant cancer cells. 

Cancer Research. 2007 Aug 1; 67 (15), 7327-7334.

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