2026
43. (Co-corresponding) Joo-Young Lim†, Jisu Hong†, Su Hyeon Lee†, Seul-Gi Lee, Byeong-Ho Chae, Minho Park, Tae Hyeon Yoo*, Yong-Sung Kim*, and Chang-Han Lee*, "Normalized Internalization Predicts CEACAM6 Antibody-Drug Conjugate Potency Across Cellular Contexts." Under review
42. (Co-corresponding) Joo-Yoon Chung†, Jisu Hong†, Su-Min Yee, Hye Won Lim, Dahye Lee, Sangwon Yoon, Seung-Hwan Lee, Yujin Jung, Seung Hun Shin, Song Cheol Kim, Chang-Han Lee*, Mihue Jang*. "Rapid CAR Screening and circRNA-driven CAR-NK Cells for Persistent Shed-resistant Immunotherapy." Signal Transduction and Targeted Therapy (IF: 52.7), 11, Article number: 129, 2026.
41. (Co-corresponding) Jisoo Yang†, Joong-Yub Kim†, Hyewon Lim, Minjoo Kim, Jimin Song, Hyejun Seo, Jae-Joon Yim, Bum-Joon Kim*, Chang-Han Lee*, Nakwon Kwak*. "Anti-MSAD-1 humoral immunity: A novel biomarker in NTM-PD." AJRCCM (IF: 19.4), 2026.
40. (Co-corresponding) Jisu Hong, Soojin Lee, Youngju Kim, Chang Kyung Kang, Wan Beom Park, Hyun Mu Shin, Hang-Rae Kim, Chang-Han Lee. "Optimization of CAR Monocytes Utilizing CD32a Signaling Phagocytosis for Antigen-Specific T Cell Activation." Scientific Reports, 2026.
39. Jihui Han, June-Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang-Han Lee, Inhee Mook‐Jung. "Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition." Advanced Science, 2026; e13135.
2025
38. Hayoung Kwon, Chang-Han Lee. "The Emergence of a New Paradigm with Signal 1 and Signal 2 T-cell Engagers in Hematology." Seminars in Hematology, 2025 Aug; 62(4): 245-254.
37. Sujin Park, Wooyeop Jeong, Yubeen Kim, Chang-Han Lee, Chaok Seok. "Artificial Intelligence in Therapeutic Antibody Design: Advances and Future Prospects." Current Opinion in Structural Biology (IF: 2.5), 2025 Oct; 94:103084.
2024
36. (Co-corresponding) Hae Nim Lee†, Soojin Lee†, Jisu Hong†, Hyejin Yoo, Jiyun Jeong, Yong-Woo Kim, Hyun Mu Shin, Mihue Jang*, Chang-Han Lee*, Hang-Rae Kim*, Jihye Seong*. "Novel FRET-Based Immunological Synapse Biosensor for the Prediction of CAR-T Cell Function." Small Methods (IF: 10.7), 2024 Sep 11.
35. (Corresponding) Minju Kim†, Xuelian Bai†, Hyewon Im, Jisoo Yang, Youngju Kim, Minjoo MJ Kim, Yeonji Oh, Yuna Jeon, Hayoung Kwon, Seunghyun Lee*, Chang-Han Lee*. "Construction and validation of a synthetic phage-displayed nanobody library." Korean Journal of Physiology & Pharmacology (IF: 2.0), 2024.
34. Chang Kyung Kang, Youngju Kim, Hyeon Jae Jo, Chan Mi Lee, Nam Joong Kim, Chang-Han Lee, Pyoeng Gyun Choe, Wan Beom Park, Myoung-don Oh. "Positivity of anti-SARS-CoV-2 nucleocapsid antibody 3 years post COVID-19." Japanese Journal of Infectious Diseases (IF: 2.2), 2024; doi: 10.7883/yoken.JJID.2024.011.
2023
33. (Co-corresponding) Chan Mi Lee, Minji Kim, Seong-wook Park, Chang Kyung Kang, Pyoeng Gyun Choe, Nam Joong Kim, Hyeon Jae Jo, Hyun Mu Shin, Chang-Han Lee, Hang-Rae Kim, Wan Beom Park, Myoung-don Oh. "Clinical outcomes and immunological features of COVID-19 in patients receiving B-cell depleting therapy during the Omicron era." Infectious Diseases (IF: 5.8), 2023 Nov 02.
32. (Co-first) Ik Soo Kim, Chang Kyung Kang, Seung Jae Lee, Chang-Han Lee, Minji Kim, Chaehwa Seo, Gwanghun Kim, Soojin Lee, Kyoung Sun Park, Euijin Chang, Jongtak Jung, Kyoung‐Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim, Myoung‐don Oh, Jong‐Eun Lee, Hyun Mu Shin, Hang‐Rae Kim. "Tracking Antigen-Specific TCR Clonotypes in SARS-CoV-2 Infection Reveals Distinct Severity Trajectories." Journal of Medical Virology (IF: 12.7), 2023; 95:e29199. doi:10.1002/jmv.29199.
31. Chan Mi Lee, Pyoeng Gyun Choe, Chang Kyung Kang, Eunyoung Lee, Kyoung-Ho Song, Ji Hwan ang, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim, Hang-Rae Kim, Youngju Kim, Chang-Han Lee, Hyun Mu Shin, Sang-Won Park, Wan Beom Park, Myoung-don Oh. "Low humoral and cellular immune responses early after breakthrough infection may contribute to severe COVID-19." Frontiers in Immunology (IF: 8.786), 2023.
30. (Co-corresponding) Chang Kyung Kang, Min-Gang Kim, Seong-wook Park, Yong-Woo Kim, Chan Mi Lee, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Minji Kim, Soojin Lee, Ik Soo Kim, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Myoung-don Oh. "Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted individuals." Journal of Medical Virology (IF: 20.693), 2023 Feb 8; 95(2): e28558.
2022
29. Chanho Kong, Eun-Jeong Yang, Jaewoo Shin, Junwon Park, Si-Hyun Kim, Seong-Wook Park, Won Seok Chang, Chang-Han Lee, Hyunju Kim, Hye-Sun Kim, Jin Woo Chang. "Enhanced delivery of a low dose of aducanumab via FUS in 5× FAD mice, an AD model." Translational Neurodegeneration (IF: 9.883), 2022; 11(1):57.
28. Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon, Sang-Kyu Ye. "The acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells." BMC Cancer (IF: 4.672), 2022; 22:852.
27. Jinyong Kim, Jiyun Jeong, Chan Mi Lee, Dae-Won Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Nam Joong Kim, Myoung-don Oh, Chang-Han Lee, Wan Beom Park, Kyung-Hun Lee, Seock-Ah Im. "Prospective Longitudinal Analysis of Antibody Response after standard and booster doses of SARS-COV2 vaccination in patients with early breast cancer." Frontiers in Immunology (IF: 8.786), 2022 Nov 17.
26. (Co-corresponding) Chang Kyung Kang, Hyun Mu Shin, Pyoeng Gyun Choe, Jiyoung Park, Jisu Hong, Jung Seon Seo, Yung Hie Lee, Euijin Chang, Nam Joong Kim, Minji Kim, Yong-Woo Kim, Hang-Rae Kim, Chang-Han Lee, Jun-Young Seo, Wan Beom Park, Myoung-don Oh. "Broad humoral and cellular immunity elicited by one dose mRNA vaccination 18 months after SARS-CoV-2 infection." BMC Medicine (IF: 11.806), 2022; 20:181.
25. (Co-corresponding) Pyoeng Gyun Choe, Jisu Hong, Jiyoung Park, Euijin Chang, Chang Kyung Kang, Nam Joong Kim, Chang-Hane Lee, Wan Beom Park, Myoung-Don Oh. "Persistent Antibody Responses up to 18 Months after Mild SARS-CoV-2 Infection." Journal of Infectious Disease (IF: 7.759), 2022 Mar 17.
24. (Co-corresponding) Chang Kyung Kang, Minji Kim, Jisu Hong, Gwanghun Kim, Soojin Lee, Pyoeng Gyun Choe, Nam Joong Kim, Ik Soo Kim, Jun-Young Seo, Daesub Song, Dong-Sup Lee, Hyun Mu Shin, Chang-Han Lee, Wan Beom Park, Hang-Rae Kim, Myoung-don Oh. "Distinctive immune response after one-year post COVID-19 according to the severity." Frontiers in Immunology (IF: 8.756), 2022 Mar 21; 13:830433.
23. Han-Seok Jeong, Da-Hye Lee, Seung-Hoon Kim, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Chung-Hyun Cho. "Hyperglycemia-induced oxidative stress promotes tumor metastasis by upregulating vWF expression in endothelial cells through the transcription factor GATA1." Oncogene (IF: 9.867), 2022 Jan 29.
22. (Corresponding) Chang-Han Lee*, George Delidakis. "Engineering IgG1 Fc domains that activate the complement system." Methods in Molecular Biology - Immune Receptors, 2022; 2421:187-200.
2021
21. (Corresponding) Ji-Young Park, Chang-Han Lee. "Will ETA Antibodies Arouse New Interest in Cancer Therapeutics?" Trends in Pharmacological Sciences (IF: 14.819), 2021 Dec 09.
20. Jie Li, Sam A Bazzi, Florian Schmitz, Hidetaka Tanno, Jonathan R McDaniel, Chang-Han Lee, Chaitanya Joshi, Jin Eyun Kim, Nancy Monson, Benjamin M Greenberg, Kristina Hedfalk, Esther Melamed, Gregory C Ippolito. "Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder." Neurol Neuroimmunol Neuroinflamm (IF: 7.724), 2021 Jun 24; 8(5):e1034.
19. (Corresponding) Seung Hyun Kang, Chang-Han Lee*. "Development of therapeutic antibodies and modulating the characteristics of therapeutic antibodies to maximize the therapeutic efficacy." Biotechnology and Bioprocess Engineering, 2021 Jun 28.
18. Chang Kyung Kang, Minji Kim, Soojin Lee, Gwanghun Kim, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Chang-Han Lee, Ik Soo Kim, Keehoon Jung, Dong-Sup Lee, Hyun Mu Shin, Hang-Rae Kim, Myoung-don Oh. "Longitudinal Analysis of Human Memory T-Cell Response according to the Severity of Illness up to 8 Months after SARS-CoV-2 Infection." Journal of Infectious Diseases, 2021 Mar 23.
2020
17. Aram Lyu, Todd A Triplett, Seo Hee Nam, Zicheng Hu, Dhivya Arasappan, Wesley H Godfrey, Rachel Y Ames, Adviti Sarang, Hilary J Selden, Chang-Han Lee, George Georgiou, Terzah M Horton, Lauren IR Ehrlich. "Tumor-associated myeloid cells provide critical support for T-ALL." Blood, 2020 July 7.
Before 2019
16. Jiwon Lee, Bryan S. Der, Christos S. Karamitros, Wenzong Li, Nicholas M. Marshall, Oana I. Lungu, Aleksandr E. Miklos, Jianqing Xu, Tae Hyun Kang, Chang-Han Lee, Bing Tan, Randall A. Hughes, Sang Taek Jung, Gregory C. Ippolito, Jeffrey J. Gray, Yan Zhang, Brian Kuhlman, George Georgiou, Andrew D. Ellington. "Computer‐based engineering of thermostabilized antibody fragments." AIChE Journal, 2019 Nov 19.
15. (Co-first) Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou. "An Engineered Human Fc Domain that Behaves like a pH-Toggle Switch for Ultra-Long Circulation Persistence." Nature Communications, 2019 Nov 6; 10:5031.
14. (Co-first) Tae Hyun Kang, Chang-Han Lee, George Delidakis, Jiwon Jung, Odile Richard-Le Goff, Jiwon Lee, Wissam Charab, Pierre Bruhns, George Georgiou. "An Engineered Human Fc variant with Exquisite Selectivity for FcγRIIIaV158 Reveals that Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis with GM-CSF-differentiated Macrophages." Frontiers in Immunology, 2019 Mar 27; 10:562.
13. Jonathan R. McDaniel, Stephanie C. Pero, William N. Voss, Girja S. Shukla, Yujing Sun, Sebastian Schaetzle, Chang-Han Lee, Andrew P. Horton, Seth Harlow, Jimmy Gollihar, Jared W. Ellefson, Christopher C. Krag, Yuri Tanno, Nikoletta Sidiropoulos, George Georgiou, Gregory C. Ippolito, David N. Krag. "Identification of Tumor-Reactive B Cells and Systemic IgG in Breast Cancer Based on Clonal Frequency in the Sentinel Lymph Node." Cancer Immunology, Immunotherapy, 2018 May; 67(5): 729-738.
12. (First) Chang-Han Lee, Gabrielle Romain, Wupeng Yan, Makiko Watanabe, Wissam Charab, Biliana Todorova, Jiwon Lee, Kendra Triplett, Moses Donkor, Oana I Lungu, Anja Lux, Nicholas Marshall, Margaret A Lindorfer, Odile Richard-Le Goff, Bianca Balbino, Tae Hyun Kang, Hidetaka Tanno, George Delidakis, Corrine Alford, Ronald P Taylor, Falk Nimmerjahn, Navin Varadarajan, Pierre Bruhns, Yan Jessie Zhang, George Georgiou. "IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector function." Nature Immunology, 2017 Aug; 18(8): 889-898.
Highlighted by Cees E van der Poel & Michael C Carroll, APS, and ALS.
Recommended by Cancer Immunology Research Journal.
11. Jiwon Lee, Daniel R Boutz, Veronika Chromikova, M Gordon Joyce, Christopher Vollmers, Kwanyee Leung, Andrew P Horton, Brandon J DeKosky, Chang-Han Lee, Jason J Lavinder, Ellen M Murrin, Constantine Chrysostomou, Kam Hon Hoi, Yaroslav Tsybovsky, Paul V Thomas, Aliaksandr Druz, Baoshan Zhang, Yi Zhang, Lingshu Wang, Wing-Pui Kong, Daechan Park, Lyubov I Popova, Cornelia L Dekker, Mark M Davis, Chalise E Carter, Ted M Ross, Andrew D Ellington, Patrick C Wilson, Edward M Marcotte, John R Mascola, Gregory C Ippolito, Florian Krammer, Stephen R Quake, Peter D Kwong, George Georgiou. "Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination." Nature Medicine, 2016 Dec; 22(12):1456-1464.
10. Bo Wang, Chang-Han Lee, Erik Johnson, Christien A. Kluwe, Josephine Cunningham, Hidetaka Tanno, Richard Crooks, George Georgiou, Andrew D. Ellington. "Discovery of High Affinity anti-Ricin Antibodies by B Cell Receptor Sequencing and by Yeast Display of Combinatorial V-H:V-L Libraries from Immunized Animals." MAbs, 2016 Jun 24; 8(6): 1035-1044.
9. Bo Wang, Christien A Kluwe, Oana I Lungu, Brandon J DeKosky, Scott A Kerr, Erik L Johnson, Hidetaka Tanno, Chang-Han Lee, Jiwon Jung, Alec B Rezigh, Sean M Carroll, Ann N Reyes, Janelle R Bentz, Itamar Villanueva, Amy L Altman, Robert A Davey, Andrew D Ellington, George Georgiou. "Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining." Scientific Reports, 2015 Sep 10; 5:13926.
8. William Kelton, Nishant Mehta, Wissam Charab, Jiwon Lee, Chang-han Lee, Takaaki Kojima, Tae Hyun Kang, George Georgiou. "IgGA: A “Cross-Isotype” Engineered Human Fc Antibody Domain that Displays Both IgG-like and IgA-like Effector Functions." Chemistry & Biology, 2014 Dec 18; 21(12): 1603-1609.
7. Kyung-Jin Park, Chang-Han Lee, Aeyung Kim, Ki Jun Jeong, Chul-Ho Kim, Yong-Sung Kim. "Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death." Journal of Biological Chemistry, 2012 Jan; 287(5): 3313-3325.
6. Seung Hoon Jang, Chang Han Lee, Yong Sung Kim, Ki Jun Jeong. "High-level production of a kringle domain variant by high-cell-density cultivation of Escherichia coli." Applied Microbiology and Biotechnology, 2011 Oct; 92(2): 327-336.
5. (First) Chang-Han Lee, Kyung-Jin Park, Sang Jick Kim, Ohsuk Kwon, Ki Jun Jeong, Ayeung Kim, Yong-Sung Kim. "Generation of bivalent and bispecific Kringle single domains by loop grafting as potent agonists against death receptor 4 and 5." Journal of Molecular Biology, 2011 Aug 5; 411(1):201-219.
4. (First) Chang-Han Lee, Kyung-Jin Park, Eun-Sil Sung, Aeyung Kim, Ji-Da Choi, Jeong-Sun Kim, Soo-Hyun Kim, Myung-Hee Kwon, Yong-Sung Kim. "Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo." PNAS, 2010 May 11; 107:9567-9571.
3. (First) Chang-Han Lee, Dong-Ki Choi, Hye-Ji Choi, Moo-Young Song, Yong-Sung Kim. "Expression of soluble and functional human neonatal Fc receptor in Pichia pastoris." Protein Expression and Purification, 2010 May 1; 71:42-48.
2. Kyung-Jin Park, Seung-Hyun Lee, Chang-Han Lee, Ji-Young Jang, Junho Chung, Myung-Hee Kwon, Yong-Sung Kim. "Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death." Biochemical and Biophysical Research Communications, 2009 May 15; 382(4):726-9.
1. Kyung-Jin Park, Seung-Hyun Lee, Tae-In Kim, Hae-Won Lee, Chang-Han Lee, Eun-Hee Kim, Ji-Young Jang, Kyeong Sook Choi, Myung-Hee Kwon, Yong-Sung Kim. "A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and resistant cancer cells." Cancer Research, 2007 Aug 1; 67(15): 7327-7334.